RECENT PUBLICATIONS:

Everett, K.L., Bunney, T.D., Yoon, Y., Rodrigues-Lima, F.,Harris, R., Driscoll P.C., Abe, K., Fuchs, H., Hrabe de Angelis, M., Yu, P., Cho, W.,and Katan, M. (2009). Characterization of phospholipase C gamma enzymes with gain-of-functionmutations. J Biol Chem 284,23083-93. Text

Bunney, T.D., Opaleye, O., Roe, M., Vatter, P., Baxendale, R.W., Walliser, C., Everett, K.L., Josephs, M.B., Christow, C., Rodrigues-Lima, F., Gierschik, P., Pearl, L.H., and Katan, M. (2009). Structural insights into formation of an active signalling complex between Rac and phospholipase C gamma 2. Molecular Cell 34,223-233. Text

Gandarillas, N.L., Bunney, T.D., Josephs, M.B., Gierschik, P., and Katan, M. (2009). In vitro reconstitution of activation of PLCepsilon by Ras and Rho GTPases. Methods Mol Biol 462, 379-389. Text

Peak, J.C., Jones, N.P., Hobbs, S., Katan, M., and Eccles, S.A. (2008). Phospholipase C gamma 1 regulates the Rap GEF1-Rap1 signalling axis in the control of human prostate carcinoma cell adhesion. Oncogene 27, 2823-2832. Text

Grant, D.M., Zhang, W., McGhee, E.J., Bunney, T.D., Talbot, C.B., Kumar, S., Munro, I., Dunsby, C., Neil, M.A., Katan, M., and French, P.M. (2008). Multiplexed FRET to image multiple signaling events in live cells. Biophys J 95, L69-71. Text

Walliser, C., Retlich, M., Harris, R., Everett, K.L., Josephs, M.B., Vatter, P., Esposito, D., Driscoll, P.C., Katan, M., Gierschik, P., and Bunney, T.D. (2008). rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem 283, 30351-30362. Text

Miertzschke, M., Stanley, P., Bunney, T.D., Rodrigues-Lima, F., Hogg, N., and Katan, M. (2007). Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration. J Biol Chem 282, 30629-30642.Text

Jones, N.P., and Katan, M. (2007). Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Biol 27, 5790-5805. Text

Grant, D., McGinty, J., McGhee, E.J., Talbot, C.B., Bunney, T.D., Owen, D.M., Kumar, S., Munro, I., Zhang, W., Lanigan, P., Kennedy, G., Dunsby, G., Magee, A.I., Courtney, P., Katan, M., Neil, M.A.A., and French, P.M.W. (2007). High speed optically sectioned fluorescence lifetime imaging permits study of live cell signalling events. Optics Express 15, 15656-15673. Text

Bunney, T.D., and Katan, M. (2006). Phospholipase C epsilon: linking second messengers and small GTPases. Trends Cell Biol 16, 640-648. Text

Bunney, T.D., Harris, R., Gandarillas, N.L., Josephs, M.B., Roe, S.M., Sorli, S.C., Paterson, H.F., Rodrigues-Lima, F., Esposito, D., Ponting, C.P., Gierschik, P., Pearl, L.H., Driscoll, P.C., and Katan, M. (2006). Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Molecular Cell 21, 495-507. Text

Hinkes, B., Wiggins, R.C., Gbadegesin, R., Vlangos, C.N., Seelow, D., Nurnberg, G., Garg, P., Verma, R et al. (2006). Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 38, 1397-1405. Text

Jones, N.P., Peak, J., Brader, S., Eccles, S.A., and Katan, M. (2005). PLCgamma1 is essential for early events in integrin signalling required for cell motility. J Cell Sci 118, 2695-2706. Text

Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T.D., Kunder, S., Quintanilla-Martinez et al. (2005). Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 22, 451-465. Text

Katan, M. (2005). New insights into the families of PLC enzymes: looking back and going forward. Biochem J 391, e7-9. Text